Lab Test Instructions
As a functional medicine practice, we often see patients that just feel “not quite right” – where there is no one dominant symptom that can point us in the right direction. Examples can range from chronic bloating, unexplained headaches or migraines, chronic fatigue, insomnia, to any number of vague symptoms.
Beyond exploring possible lifestyle factors to identify the root cause of chronic disease or wellness challenges, we frequently use advanced functional medicine lab testing that provide valuable information about health at the cellular level.
The test results help guide our treatment recommendations in major ways – allowing us to craft an approach unique to your situation, genetics, and biochemistry.
Organic Acids Testing
The Organic Acids Test (OAT) offers a comprehensive metabolic snapshot of a patient’s overall health with 76 markers. It provides an accurate evaluation of intestinal yeast and bacteria. Abnormally high levels of these microorganisms can cause or worsen behavior disorders, hyperactivity, movement disorders, fatigue and immune function.
Many people with chronic illnesses and neurological disorders often excrete several abnormal organic acids in their urine. The cause of these high levels could include oral antibiotic use, high sugar diets, immune deficiencies, acquired infections, as well as genetic factors. Organic Acids Test also includes markers for vitamin and mineral levels, oxidative stress, neurotransmitter levels, and is the only OAT to include markers for oxalates, which are highly correlated with many chronic illnesses. If abnormalities are detected using the OAT, treatments can include supplements, such as vitamins and antioxidants, or dietary modification.
Upon treatment, patients and practitioners have reported significant improvement such as decreased fatigue, regular bowel function, increased energy and alertness, increased concentration, improved verbal skills, less hyperactivity, and decreased abdominal pain. The OAT is strongly recommended as the initial screening test.
Here’s a patient’s guide link: Click Here
GI Effects Stool Test
The GI Effects Microbial Ecology Profile is the most comprehensive group of stool tests that assess the diverse gut microbiome. Results provide immediate, actionable clinical information for the management of detectable parasites, bacteria, and yeast, as well as providing valuable assessment of gut microbiota via 24 Commensal Bacteria targets.
The GI Effects Microbial Ecology Profile is part of the larger GI Effects Comprehensive Stool Profile, which also provides information about digestion, inflammation, and bacterial metabolism markers. A larger fecal biomarker panel such as the GI Effects Comprehensive Stool Profile offers the advantage of assessing multiple functional areas that may be contributing to symptoms. For example, diarrhea could stem from multiple causes including pancreatic exocrine insufficiency, inflammation, food allergies, or the presence of a pathogenic or potentially pathogenic organism.
Here’s a patient’s guide for GI Effects: Click Here
Insulin Resistance Panel
Insulin resistance and consequent β-cell failure are the core pathophysiologic defects that lead to T2D. Clinical trials have shown that lifestyle or pharmacological interventions that elicit weight loss and increase insulin sensitivity may delay the onset of T2D. However, many of the methods used to assess insulin sensitivity/resistance in clinical studies are costly and time-consuming, limiting their use in the primary care setting. In contrast, LP-IR is a simple test for assessing insulin resistance that combines six simultaneously-measured lipoprotein parameters that each are associated with insulin resistance and T2D [large very low density lipoprotein particle number (large VLDL-P), VLDL size, small low density lipoprotein particle number (small LDL-P), LDL size, large high density lipoprotein particle number (large HDL-P) and HDL size].
The LP-IR score exhibits a strong, graded relation with independent measures of insulin resistance, including HOMA-IR and glucose disposal rate measured by the gold-standard hyperinsulinemic-euglycemic clamp method, the former being more reflective of hepatic and the latter of peripheral insulin sensitivity.
The LP-IR score thus offers a simple, reliable way to assess a patient’s insulin resistance status in a clinical setting.
Patient Link: www.labcorp.com/assets-media/2307
In individuals with insulin resistance (IR), cells become less sensitive to the effects of insulin and do not absorb enough glucose from the bloodstream. IR can progress to prediabetes and type 2 diabetes mellitus (DM).
IR is also associated with other clinical conditions, including hypertension, cardiovascular disease, stroke, nonalcoholic fatty liver disease, polycystic ovary syndrome, and certain forms of cancer.
Early recognition and intervention can help reverse IR or prevent its progression, and thereby reduce the risk of these clinical conditions.
Patient Link: Click Here